Alzheimers disease
Conditions
Interventions
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects undergoing lymphatic anastomosis for Alzheimer's disease under elective general anesthesia; 2. Age, gender is not limited; 18 kg/m2<=body mass index<=28 kg/m^2; 3. Preoperative ASA grade II.~III; 4. Patients and/or their legal guardians agree to participate in this trial and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Known or suspected allergy or contraindication to the drugs required in the study; 2. Clinician-judged patients with abnormal liver and kidney function (ALT and AST> 1.5 times the upper limit of normal; BUN and/or or Urea >1.5 times the upper limit of normal; Cr >upper limit of normal; dialysis treatment within 28 days prior to surgery), or clinically significant coagulation abnormalities (PT or APTT or TT > upper limit of normal), or those with poor blood pressure control (sitting SBP>160mmHg or SBP=III), unstable angina, and acute myocardial infarction in the past 6 months; 10. Those who have chronic (3 consecutive months or up to 6 months) pain related to non-surgical sites, or long-term (continuous use for 4 weeks or more) analgesics (including opioids and NSAIDs); 11. Those who have a history of drug abuse, drug abuse and alcohol abuse within 2 years before screening. Alcoholism is defined as regular alcohol consumption of more than 14 times/week (1 ˜ 150 mL of wine or 360 mL of beer or 45 mL of spirits); 12. Monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, serotonin norepinephrine reuptake inhibitors (SNRIs), and serotonin reuptake inhibitors (SSRIs) within two weeks prior to the first dose; 13. Those who have participated in any clinical trial within 3 months before the first dose; 14. Other circumstances judged by the investigator to be unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CAM, MMSE, MOCA, CDR scale assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain functional status monitor parameters;ADL scale and postoperative related parameters; | — |
Countries
China
Contacts
Public ContactLuo Foquan
Zhejiang Provincial People's Hospital
Outcome results
None listed