Severe traumatic brain injury
Conditions
Interventions
Multimodal Monitoring Group:None
Routine Monitoring Group:None
Sponsors
Beijing Children's Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 1 year and < 18 years; 2. A clear history of head trauma and admission to PICU within 24 hours after injury; 3. Diagnosed with TBI based on medical history, clinical symptoms, signs, and imaging data, with a GCS score <=8 at admission; 4. ICP monitoring agreed upon by the family; 5. Continuous ICP and MAP monitoring for at least 72 hours.
Exclusion criteria
Exclusion criteria: 1. Congenital cerebrovascular malformation; 2. TBI damaging the bilateral temporal bone windows, making TCD examination impossible; 3. Use of thrombolytic or anticoagulant drugs, or long-term use of antihypertensive drugs in the past; 4. Those who meet the criteria for determination of pediatric brain death based on cerebral function assessment during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival rate after discharge; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in PICU;Duration of invasive mechanical ventilation;Total length of hospital stay;Glasgow score;Pediatric Cerebral Performance Category Score?; | — |
Countries
China
Contacts
Public ContactWang Quan
Beijing Children's Hospital, Capital Medical University
Outcome results
None listed