Gastrointestinal diseases
Conditions
Interventions
A1 group:Remimazolam 0.3 mg/kg administered as a bolus injection within 15 seconds.
A2 group:Remimazolam 0.3 mg/kg administered as a bolus injection within 15-30 seconds.
A3 group:Remimazolam 0.3 mg/kg administered as a bolus injection within 30-60seconds.
B1 group:Remimazolam 0.4 mg/kg administered as a bolus injection within 15 seconds.
B2 group:Remimazolam 0.4 mg/kg administered as a bolus injection within 15-30 seconds.
B3 group:Remimazolam 0.4 mg/kg administered as a bolus injection within 30-60 seconds.
Sponsors
Chengdu Intergrated TCM&Western Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-65 years, gender unrestricted; 2.Body mass index 18-24 kg/m²; 3.Only eligible for painless colonoscopy procedures; 4.American Society of Anesthesiologists (ASA) Physical Status Classification Class I-II.
Exclusion criteria
Exclusion criteria: 1.Drug allergy; 2.Patients with schizophrenia, severe depression, or other psychiatric disorders requiring long-term psychotropic 3.medication; 4.Patients with difficult airway identified during preoperative evaluation; 5.History of infection, surgery, or trauma within 1 month prior to enrollment; Other conditions deemed ineligible for clinical trial participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time of hiccup occurrence;Frequency of hiccups;Duration of hiccups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure before drug administration;The mean arterial pressure 1 minute after drug administration.; the heart rate before drug administration;The heart rate 1 minute after drug administration;The time from drug injection to the disappearance of the eyelash reflex.;Number of additional drug administrations.;The time of additional drug administration.;Colonoscopy procedure time.;Time to awakening.; | — |
Countries
China
Contacts
Public ContactYanping Lu
Chengdu Intergrated TCM&Western Medicine Hospital
Outcome results
None listed