Eosinophilic Chronic Rhinosinusitis with Nasal Polyps
Conditions
Interventions
Control group:ESS
Experimental group:ESS with posterior nasal neurectomy (PNN)
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–60 years, both sexes. 2.Meet the EPOS2020 diagnostic criteria for chronic rhinosinusitis with nasal polyps (CRSwNP). 3.Refer to JESREC diagnostic criteria: >=11 points indicate eosinophilic (EOS) infiltration type CRSwNP. 4.Peripheral blood total IgE >=100 U/mL. 5.Pathological tissue EOS >10/high-power field (HPF).
Exclusion criteria
Exclusion criteria: 1.Patients who have used any form of oral hormones, antibiotics, or antihistamines within 4 weeks before enrollment. 2.Patients who have a history of upper respiratory tract infection or asthma attack within 2 weeks before enrollment. 3.Pregnant or lactating patients. 4.Patients with severe underlying diseases (poorly controlled diabetes, hypertension, rheumatic immune system diseases requiring long - term use of hormones, etc.), or those with other tumors or systemic diseases. 5.Patients who are currently participating in clinical trials, or have participated in other clinical trials within the past 30 days, or are personnel involved in this study. 6.People with a history of mental illness, or other emotional or intellectual problems, or those who cannot understand the informed consent or subjective assessment forms due to language problems.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lund-Kennedy score; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;SNOT-22 score;Time Cost;Economic Cost;Adverse reaction; | — |
Countries
China
Contacts
Public ContactXifu Wu
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed