coronary heart disease
Conditions
Interventions
Combination therapy group:Conventional thrombus aspiration, tirofiban intravenous loading dose in coronary artery and intravenous pump were used according to kg body weight for 24 hours, and 1/3 of th
Thrombus aspiration group:After conventional thrombus aspiration, stent implantation (pre expansion and post expansion if necessary) was performed. Tirofiban was given intravenous load according to kg
Sponsors
Zhoupu Hospital, Pudong New Area, Shanghai
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (1) 18-80 years old, male or female; (2) STEMI was diagnosed according to the typical symptoms of persistent angina pectoris, ECG and troponin I (2 or more of the three criteria were positive); (3) The family members signed for emergency PCI treatment; (4) Coronary angiography showed complete or subtotal occlusion of the coronary artery, and the TIMI thrombus grade was greater than or equal to 4 points after the guide wire and 2.0mm balloon passed through the target vessel segment (TIMI thrombus score standard: 0, no thrombus); 1 point, blurred thrombus shadow; The length of thrombus was less than 1/2 and 3 of the normal vessel diameter. The length of thrombus was between 1/2 and 2 times of the vessel diameter; 4 points, the confirmed thrombus, with a length greater than 2 times the inner diameter of the blood vessel; 5 points, complete vascular occlusion).
Exclusion criteria
Exclusion criteria: Exclusion criteria: (1) hemoglobin was less than 120g/L in males and less than 120g/L in females; (2) History of cerebral hemorrhage or gastrointestinal hemorrhage in recent 3 months; (3) ALT was more than 2 times the upper limit of normal value or CCR was more than 3mg/dl; (4) Previously known allergy to tirofiban; (5) During pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Index of microcirculation resistance; | — |
Countries
China
Contacts
Public ContactZhishan SUN
Zhoupu Hospital, Pudong New Area, Shanghai
Outcome results
None listed