Septic liver dysfunction
Conditions
Interventions
Sepsis liver injury group:NA
Sponsors
The First Affiliated Hospital of Gannan Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of sepsis 3.0; Hospital stay > 1 day; Positive evidence of a clear source of infection or bacterial culture; 2. Diagnostic criteria for hepatic damage in sepsis: bilirubin >34.2 µmol/L (2 mg/dL) and coagulation disorder with international normalized ratio (INR) >1.5.
Exclusion criteria
Exclusion criteria: Duration of hospitalization <=1 d; Chronic liver disease or acute onset of chronic liver dysfunction; Drug-induced liver injury; Obstructive jaundice; Liver cirrhosis; Suffering from acute or chronic infectious diseases; Chemoradiotherapy was performed within 3 months. Fatal trauma victim.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Procalcitonin;Neutrophil;Lactic acid;Total bilirubin;Aspartate aminotransferase;Alanine aminotransferase;Prothrombin time;International normalized ratio;Activated partial thromboplastin time;Fibrinogen;Thrombin time;Treatment situation;Sequential organ failure score;Total bile acids;Prothrombin activity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Site of infection;Acute physiology and chronic health scores II; | — |
Countries
China
Contacts
Public ContactWang Bin
The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, China
Outcome results
None listed