Venous Thromboembolism
Conditions
Interventions
Pulmonary embolism group:N/A
Without pulmonary embolism group:N/A
Intervention group:Interventional thrombectomy was performed within 48 hours after the start of anticoagulation therapy, and an 8F thrombectomy catheter was inserted with the aid of contrast to aspira
Drug group:Drug anticoagulant therapy, heparin drugs were given immediately after diagnosis, ordinary heparin was continuously pumped, and APTT was monitored to maintain at 50-70s. Or low molecular we
Sponsors
Beijing Chaoyang Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Sub-project 1: (1) Patients diagnosed with DVT by ultrasound or CT examination; (2) Age :18 years old or above; (3) Voluntarily participate in the study and sign the informed consent. Sub-project 2: (1) Meet the diagnostic criteria for moderate and high-risk PTE: 1) CTPA showed right ventricular end-diastolic diameter/left ventricular end-diastolic diameter > 0.9; 2) At least one cardiac biomarker was elevated, including BNP, NT-pro BNP, and troponin. (2) CTPA indicated that thrombus was located in the lobar artery and above; (3) at least 18 years old; (3) Voluntarily participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: Sub-project 1: (1) Pregnant women and children under 18 years of age; (2) Allergic subjects with iodine contrast agent; (3) Patients with chronic kidney disease or renal insufficiency (creatinine clearance =70 mmHg as estimated by cardiac color ultrasound). (2) Patients who are allergic to contrast media and cannot undergo iodine contrast media examination and interventional therapy. (3) Patients with chronic kidney disease or renal insufficiency (creatinine clearance < 30 ml/min) who could not tolerate angiography. (4) Patients with left heart cardiovascular diseases such as left bundle branch block who cannot tolerate interventional therapy. (5) Patients with high risk of interventional operation after pacemaker implantation within 1 month. (6) Uncontrolled hyperthyroidism is not suitable for angiography. (7) Pregnant women. (8) With other serious diseases, the expected survival time is less than 3 months. (9) Do not agree to enter clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary embolism;Right ventricular to left ventricular ratio, RV/LV;Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism; | — |
Secondary
| Measure | Time frame |
|---|---|
| Routine blood examination;D-dimer; | — |
Countries
China
Contacts
Public ContactQi Yang
Beijing Chaoyang Hospital, Capital Medical University
Outcome results
None listed