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A Macrophage-Targeted Delivery System Based on ionic equilibrium strategy for the Treatment of Diabetic Peri-implantitis

A Macrophage-Targeted Delivery System Based on ionic equilibrium strategy for the Treatment of Diabetic Peri-implantitis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500099247
Enrollment
Unknown
Registered
2025-03-20
Start date
2025-04-01
Completion date
Unknown
Last updated
2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Peri-implantitis

Interventions

People diagnosed with diabetes and suffering from peri-implantitis:None
People diagnosed with diabetes but not suffering from peri-implantitis:None
People with peri-implantitis who are not diabetic:None
People without peri-implantitis or diabetes mellitus:None

Sponsors

West China Hospital of Stomatology, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years; 2. Informed consent and signing of relevant instruments by the patient; 3. Single implant;

Exclusion criteria

Exclusion criteria: 1. Age <18 years; 2. Patient refuses to participate in the trial/signs the relevant informed consent form; 3. Suffering from a systemic disease other than diabetes mellitus that has an effect on the implant; 4. Use of medications with peri-implant effects within the last 6 months; 5. Having other inflammatory diseases in the oral cavity other than peri-implantitis and in the acute stage; 6. Pregnancy/nursing period.

Design outcomes

Primary

MeasureTime frame
Fasting blood levels of zinc and iron ions;Zinc and iron ions in gingival sulcus fluid;

Secondary

MeasureTime frame
Peri-implant plaque index with peri-implantitis;Gingival index of implants with peri-implantitis;Implant bleeding on probing with peri-implantitis;Depth of peri-implant probing with peri-implantitis;Implant mobility with peri-implantitis;Diagnostic imaging of alveolar bone loss with peri-implantitis;Glycosylated hemoglobin level in fasting blood;Fasting blood levels of superoxide dismutase;Indicators of oxidative stress in the gingival sulcus;Inflammatory correlates of gingival sulcus fluid;Gingival fluid osteoclast-related factor protein;

Countries

China

Contacts

Public ContactXibo Pei

West China Hospital of Stomatology, Sichuan University

pxb1024@scu.edu.cn+86 135 4120 2602

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026