Respiratory failure caused by community-acquired pneumonia
Conditions
Interventions
sivelestat Group:none
Control group:none
Sponsors
The First Affiliated Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18 years old to 80 years old, gender not limited; 2. Patients diagnosed with community-acquired pneumonia accompanied by respiratory failure; 3. In the study group, sivelestat was used within 72 hours after onset of illness; 4. In the study group, sivelestat was used for =5 days.
Exclusion criteria
Exclusion criteria: 1. Other pulmonary diseases (such as hospital-acquired pneumonia, interstitial lung disease, cardiogenic pulmonary edema, pulmonary embolism, bronchiectasis, etc.); 2. Patients with respiratory failure caused by non-pulmonary disease episodes (such as severe malnutrition, chronic heart failure, etc.); 3. Patients with functional failure of three or more extrapulmonary organs; 4. Pregnant or lactating women; 5. Patients with terminal malignant tumors or cachexia; 6. Patients who have been using high-dose hormones (prednisone or equivalent dose >= 1mg/kg/d) for >= 3 weeks continuously; 7. Patients participating in other exploratory clinical studies simultaneously; 8. Patients using drugs with inhibitory effect on elastase such as ulinastatin simultaneously; 9. Patients with severely missing data; 10. Patients judged by the investigators as not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The improvement situation of respiratory failure ;Clinical improvement ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate of respiratory failure;mortality rate;The rate of progression from HFNO/NIV to invasive mechanical ventilation or the rate of conversion from invasive mechanical ventilation to HFNO/NIV;Time without respiratory support;Non-mechanical ventilation time;The rate of secondary intubation;Whether to use CRRT; | — |
Countries
China
Contacts
Public ContactWang Wei
The First Affiliated Hospital of China Medical University
Outcome results
None listed