Chronic cerebral ischemia
Conditions
Interventions
Gold Standard:Arteriography findings
Index test:Hybrid PET/MR
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 50 patients with chronic unilateral ICA stenosis (subject to all of the following): 1. Angiography diagnosed unilateral anterior circulation head carotid artery stenosis, the diameter of the tube was reduced by >70%, and the contralateral anterior circulation and bilateral posterior circulation did not exceed the stenosis of >50% of the diameter reduction; 2. Must have had a transient ischemic attack or ischemic stroke within the lesion vascular area within the past 12 months, with the most recent onset being more than 3 weeks; 3. MRI showed no new infarct lesions in the skull; 4. There is no infarct lesion in the previous pontine area; 5. Any image of PET/MR blood flow and metabolic imaging shows decreased blood flow and metabolism in the hemisphere on the side of the lesion, and the reduction rate is more than 10% compared with that of the contralateral area; 6. Subjects and those in the know can complete relevant examinations and follow-ups; 7. Subjects or their authorized representatives sign the informed consent form. Enrollment criteria for the healthy control group: normal healthy people recruited in the neurosurgery clinic with gender and age matching the patient group, and no previous history of cerebral ischemia and other related diseases
Exclusion criteria
Exclusion criteria: 1. The image quality is not good due to head movement and other reasons during the scanning process; 2. Presence of other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, traumatic brain injury, normal intracranial pressure hydrocephalus, etc.); 3. Presence of other systemic diseases that can cause cognitive impairment, such as liver insufficiency, renal insufficiency, thyroid dysfunction, severe anemia, folic acid and vitamin B12 deficiency, special infections (such as syphilis, HIV), alcohol and drug abuse, etc.; 4. Presence of mental and neurodevelopmental retardation; 5. Presence of other diseases known to cause cognitive impairment; 6. Those who have severe visual and hearing impairment, claustrophobia, etc., and cannot cooperate with MRI examination; 7. Suffering from diseases that cannot cooperate with the completion of cognitive examinations; 8. Refusal to sign informed consent at baseline.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral blood flow;Glucose metabolism;Clincal score; | — |
Countries
China
Contacts
Public ContactBixiao Cui
Xuanwu Hospital Capital Medical University
Outcome results
None listed