rebound pain after peripheral nerve block
Conditions
Interventions
Sponsors
Xiangyang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: The orthopaedic patient with unilateral closed fracture of upper limb (humerus and below) in Xiangyang Central Hospital, aged 18-80years old, ASA I-III grade, who intend to undergo their first open reduction and internal fixation of unilateral fracture of upper limb (humerus and below) under brachial plexus block (intermuscular sulcus+axillary route).
Exclusion criteria
Exclusion criteria: 1. Patients undergoing combined surgeries at other sites. 2. Emergency patients; 3. Patients with peripheral neuropathy or preoperative nerve injury in the surgical limb; 4. Patients with a history of axillary surgery on the surgical side; 5. Patients with multiple surgeries (>1) on the surgical limb; 6. Patients with allergies to local anesthetics or contraindications to postoperative analgesics (e.g., NSAIDs and paracetamol); 7. Pregnant patients; 8. Patients with diabetes or vascular diseases; 9. Patients on long-term use of opioids, antipsychotics, or antidepressants; 10. Patients with infection at the injection site, acute porphyria, or kidney disease requiring dialysis; 11. Patients with contraindications to regional anesthesia, those requiring general anesthesia, or those with incomplete nerve block necessitating adjunctive general anesthesia or conversion to general anesthesia; 12. Patients with chronic pain syndromes; 13. Patients unable to comprehend perioperative questionnaires (due to language barriers or cognitive impairments); 14. Patients who have participated in similar studies within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression levels of differential genes in peripheral blood of subjects and experimental animals before and after surgery.;NRS scores at 1,2 and 3 days after surgery(resting pain, average daily pain, most severe pain, and night pain scores); | — |
Secondary
| Measure | Time frame |
|---|---|
| anxiety scores at 1,2 and 3 days after surgery;quality of sleep day 1,2 and 3;dosage of postoperative analgesics(opiods, NSAIDS);duration of analgesia and motor block;NRS scores at 1,2 and 3 days after surgery(resting pain, average daily pain, most severe pain, and night pain scores);postoperative side effects(headache, dizziness, nausea, vomiting); | — |
Countries
China
Contacts
Public ContactXingrui Gong
Xiangyang Central Hospital
Outcome results
None listed