Myelopathy
Conditions
Interventions
intervention group:Intrathecal injection of umbilical cord blood mononuclear cells combined with intravenous infusion
Sponsors
Shandong Provincial Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old, gender unlimited; 2. Clinically diagnosed myelopathy; 3. No obvious abnormalities in liver and kidney function: ALT, AST<=2.5 times the normal upper limit, serum Cr and BUN<=1.25 times the normal upper limit; 4. No obvious abnormality of cardiopulmonary function; 5. Normal immune function and immune deficiency screening; 6. Sign the informed consent in accordance with the patient's personal wishes under the premise of full knowledge.
Exclusion criteria
Exclusion criteria: 1. The vital signs are unstable; 2. Combined with malignant tumors or other major systemic diseases; 3. Patients with severe active infections, or those known to be HIV-positive, or patients with hepatitis B, hepatitis C, or syphilis. 4. Serious trauma to other organs may affect subsequent safety assessment; 5. Pregnant or breastfeeding women, women of pregnant age, with the consent of their partner, must use effective contraception before and during the study and for 6 months after the study is completed. During the study period, women should notify the doctor in charge if they suspect that pregnancy is possible; 6 Allergic reaction to the drugs or similar drugs used in this study; 7 Participating in other clinical trials; 8. Patients considered unsuitable for inclusion by other investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate at which patients achieved grade improvement on the ASIA Functional Scale;The rate at which patients achieved improvement in FIM functional scale rating;Rate of improvement in the WISCI functional scale of patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Spinal cord imaging changes of patients; | — |
Countries
China
Contacts
Public ContactFang Long
Shandong Provincial Third Hospital
Outcome results
None listed