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An observational study of the expression level of B cell subsets in HLA antibody/platelet antibody positive patients with hematological diseases and its relationship with reconstruction after transplantation

An observational study of the expression level of B cell subsets in HLA antibody/platelet antibody positive patients with hematological diseases and its relationship with reconstruction after transplantation

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500099207
Enrollment
Unknown
Registered
2025-03-19
Start date
2024-01-24
Completion date
Unknown
Last updated
2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hematological diseases

Interventions

HLA antibody/platelet antibody positive group:None
HLA antibody/platelet antibody negative group:None

Sponsors

The First Affiliated Hospital of Soochow University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients who are negative for HLA antibody/platelet antibody, and patients who are to undergo haploid allogeneic hematopoietic stem cell transplantation and who are positive for HLA antibody/platelet antibody, and who are to undergo haploid allogeneic hematopoietic stem cell transplantation after CD20 monoclonal antibody/antibody clearance therapy.

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

MeasureTime frame
Proportion of naive B cells;Proportion of pre-B cells;Proportion of GC-B cells;Proportion of Breg cells;Proportion of long-lived/short-lived plasma cell subsets;—

Countries

China

Contacts

Public ContactLiu Yuejun

The First Affiliated Hospital of Soochow University

liuyuejun111@163.com+86 139 1553 5177

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026