Helicobacter pylori infection
Conditions
Interventions
Group 1:Tetracycline 500 mg tid + Vonoprazan 20 mg bid
Group 2:Tetracycline 500 mg qid + Vonoprazan 20 mg bid
Group 3:Amoxicillin 1000 mg qid + Vonoprazan 20 mg bid
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 to 70 years; (2) Patients diagnosed with Helicobacter pylori infection positivity by urea breath test; (3) Patients who are either treatment-naïve for H. pylori or have experienced one treatment failure (with the last treatment being more than 3 months ago and the previous treatment regimen being different from the current one); (4) In Groups 1 and 2, participants may or may not be allergic to penicillin, while the control group must not be allergic to penicillin; (5) Willing to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Women in the preconception period, pregnant women, or breastfeeding women;(2) Individuals who have taken medications within the past 3 months that may affect the study results (proton pump inhibitors [PPIs], potassium-competitive acid blockers, H2 receptor antagonists [H2RAs], bismuth agents, antibiotics, antisecretory drugs, etc.);(3) Patients with =2 treatment failures for H. pylori or those who experienced one previous treatment failure with a regimen identical to the current study protocol;(4) Patients with severe systemic diseases or malignancies;(5) Patients who have previously undergone gastric or esophageal surgery;(6) Known contraindications to any of the drugs used in this study;(7) Patients who, due to advanced age, psychiatric or psychological abnormalities, or other reasons, are unable to describe adverse events.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of compliance;Factors influencing eradication rate; | — |
Countries
China
Contacts
Public ContactDe-Kui Zhang
Lanzhou University Second Hospital
Outcome results
None listed