Postoperative pain
Conditions
Interventions
Control group:0.75% bupivacaine 150 mg combined with dexamethasone 8 mg.
Experimental group:Liposomal bupivacaine 266 mg combined with 0.75% bupivacaine 50 mg.
Sponsors
The Second Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients aged 18 to 80 years, regardless of gender; scheduled to undergo thoracoscopic lobectomy under general anesthesia; BMI 15~30 kg/m^2; ASA class I ~ III; voluntarily participated and signed the informed consent form; complete clinical data available and able to complete follow-up visits.
Exclusion criteria
Exclusion criteria: Refusal to participate in this study; severe cardiac or pulmonary diseases; sinus bradycardia; heart block; chronic pain treatment or chronic steroid therapy; history of psychiatric disorders; history of allergy to the investigational drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the curve (AUC) of resting and coughing NRS scores within 72 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first postoperative analgesia;Oxycodone consumption within 72 hours postoperatively;Incidence of postoperative adverse events; | — |
Countries
China
Contacts
Public ContactMuhuo Ji
The Second Affiliated Hospital of Nanjing Medical University
Outcome results
None listed