None
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients aged between 18 and 70 years old. 2. American Society of Anesthesiologists (ASA) physical status I to II. 3. Patients undergoing elective knee arthroplasty under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Allergic to local anesthetics. 2. Contraindications to tourniquet use (infection at the block site, peripheral neuropathy, peripheral vascular disease, previous arterial bypass grafting). 3. Patients with ischemic heart disease or poorly controlled hypertension recently. 4. Tourniquet use time less than 45 minutes or more than 120 minutes. 5. Those who are unwilling to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of tourniquet-induced hypertension during surgery.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure (MAP), systolic blood pressure (SBP), and heart rate (HR) were measured at the following time points: before anesthesia (T0), 1 minute before tourniquet inflation (T1), and at 15-minute intervals after tourniquet inflation (15 [T2], 30 [T3], 45 [T4], 60 [T5], 75 [T6], and 90 minutes [T7]);The consumption of urapidil;The consumption of remifentanil;Postoperative Visual Analogue Scale (VAS) score;Postoperative quality of recovery score; | — |
Countries
China
Contacts
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University