uremic pruritus patients
Conditions
Interventions
Limonene fragrance treatment group :Two drops of lemon essential oil were applied to a 2×2cm clean gauze, which was fixed to the chest area of the patients clothing (about 10 cm from the nose), and th
placebo control group:Normal saline solution
Sponsors
Department of Nephrology, the First Affiliated Hospital, the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age :18-70 years old; 2. Patients who meet the diagnostic criteria for uremia (serum creatinine >707µmol/L) or chronic kidney disease stage 5 or above (glomerular filtration rate <15mL/min) or maintenance hemodialysis (dialysis months more than 12 months); 3. Meet the diagnostic criteria for pruritus: any of the following conditions can be diagnosed as pruritus: (1) skin pruritus symptoms appear for more than 3 days within 2 weeks, lasting a few minutes each time, occurring more than 3 times a day; (2) Skin itching in a fixed pattern for more than half a year.
Exclusion criteria
Exclusion criteria: 1. Patients with diabetic peripheral neuropathy; 2. Skin itching caused by skin diseases or blood diseases; 3. Active infection; 4. Mental illness or other communication problems; 5. Cholestatic liver disease or acute hepatitis; 6. Malignant tumors; 7. Allergic to citrus, lemon fruits and smells; 8. History of bronchial asthma, COPD and other chronic lung diseases; 9. Patients with olfactory disorders; 10. Pregnant women and women in pregnancy; 11. Other diseases with skin damage; 12. Patients who received treatment for itching within 30 days prior to screening: treatment with antihistamines and corticosteroids (oral, IV, or topical), opioids, gabapentin, and pregabalin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale values; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Duo pruritus score;Beck Depression Self-Rating Scale (BDI) score;Anxiety Self-Rating Scale (SAS) score;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactMing Bai
Department of Nephrology, Xijing Hospital, The Fourth Military Medical University
Outcome results
None listed