Perioperative Neurocognitive Disorder, PND
Conditions
Interventions
No-Postoperative delirium group:None
Sponsors
Shanghai Fourth People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age > = 65 years; 2. American Society of Anesthesiologists (ASA) grade I~IV; 3. Surgical treatment under general anesthesia; 4. Estimated operation time >= 2 h 5. Agree to participate in this study and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Outpatient surgery or day surgery (expected hospital stay of less than 48 hours); 2. Have a history of psychiatric or neurological disorders (including depression, severe central nervous system depression, schizophrenia, epilepsy and Parkinson's disease or Alzheimer's disease); 3. Preoperative use of antipsychotic drugs or opioids 4. Have a significant impairment, such as blindness, severe deafness, or dementia, that may preclude cognitive testing; 5. Participate in other research projects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium;Non-targeted metabolomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative cognitive dysfunction;Severity of delirium;Cognitive function scores;Depression self-rating scale score;Pittsburgh sleep quality index,PSQI;SAS anxiety self-measurement scale score;Barthel index of daily living ability scale score;Untargeted proteomics; | — |
Countries
China
Contacts
Public ContactCheng Li
Shanghai Fourth People's Hospital (Shanghai Fourth People's Hospital Affiliated to Tongji University)
Outcome results
None listed