Corneal disease
Conditions
Interventions
Experimental group:The investigator performs lamellar corneal transplantation according to the specific condition of the subject, and the depth
Sponsors
Henan Provincial Eye Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age of 18 to 80 years old, regardless of gender; (2) Patients with corneal disease without descemet's membrane and endothelial layer, who are scheduled for lamellar keratoplasty; (3) The subjects and/or their guardians could understand the purpose of the trial, show sufficient compliance with the trial protocol, and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) The affected eye is complicated by a disease that severely affects the ocular surface (such as severe dry eye, Sjogren's syndrome, cicatricial peebooid). sores, etc.); (2) The affected eye is combined with other ocular lesions (such as glaucoma, active uveitis, scleral staphyloma, infectious eye Internal inflammation, retinal detachment, eyelid insufficiency, ocular hypertension, etc.); (3) Patients with severe corneal vascularization; (4) Concomitant with major organ failure or other serious diseases that cannot tolerate surgery, including unintervened and severe of coronary or cardiovascular disease, or history of myocardial infarction within 12 months prior to enrollment; (5) Patients with psychiatric diseases, severe systemic diseases (such as severe diabetes mellitus (after taking glycemic control measures, Fasting blood glucose is still >= 8 mmol/L), uncontrolled hypertension above stage II (blood pressure is higher than after drug control 160~179/100~109 mmHg), rosacea); (6) History of allergy to commonly used ophthalmic drugs (tobramycin, dexamethasone, tacrolimus, etc.); (7) History of cornea or ocular surgery in the affected eye; (8) Those with severe allergies and/or allergies to the test materials; (9) Pregnant or lactating females; (10) Participation in other interventional drug clinical trials or medical device clinical trials within 3 months prior to enrollment; (11) Other situations in which the investigator believes that the investigator should not participate in this clinical trial for the benefit of the subject; (12) Corneal trauma such as severe burns or chemical injuries
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of corneal epithelial healing;Corneal thickness;Corneal transparency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Corneal curvature;Vision; | — |
Countries
China
Contacts
Public ContactWang Lulu
Henan Provincial Eye Hospital
Outcome results
None listed