Obesity
Conditions
Interventions
Detection group:Titrate PEEP using airway opening pressure and esophageal pressure
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age>=18 years old; 2.Body Mass Index (BMI)>=30 kg/m²; 3.Not diagnosed with Acute Respiratory Distress Syndrome (ARDS); 4.The patient undergoes intubation and mechanical ventilation; 5.Informed consent has been signed;
Exclusion criteria
Exclusion criteria: 1.Contraindications for esophageal catheter insertion; 2.Contraindications for Electrical Impedance Tomography (EIT) monitoring; 3.Suffering from severe chronic obstructive pulmonary disease; 4.Having a history of severe or uncontrolled asthma; 5.Having a history of lung metastasis; 6.Receiving renal replacement therapy; 7.Suffering from congestive heart failure;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| End-expiratory lung impedance (EELI);Tidal impedance variation (TIV);Local over - expansion/collapse (ODCL);Global Inhomogeneity(GI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Tidal volume;Respiratory rate;Driving pressure;Transpulmonary driving pressure;Respiratory system compliance;Arterial partial pressure of carbon dioxide, PaCO2;Index of oxygenation, P/F;Oxygen saturation, SaO2; | — |
Countries
China
Contacts
Public ContactHongping Qu
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed