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A randomized clinical neuroimaging study on the effect of acupuncture and rehabilitation therapy on brain function plasticity of motor aphasia after ischemic stroke

A randomized clinical neuroimaging study on the effect of acupuncture and rehabilitation therapy on brain function plasticity of motor aphasia after ischemic stroke

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500099159
Enrollment
Unknown
Registered
2025-03-19
Start date
2025-03-21
Completion date
Unknown
Last updated
2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Motor aphasia after stroke

Interventions

Acupuncture Rehabilitation Group:Head needle intervention
Conventional rehabilitation group:Conventional rehabilitation intervention
Healthy control group:None

Sponsors

Shanghai Seventh People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patient group: 1. Patients who meet the above diagnostic criteria for aphasia in traditional Chinese and Western medicine; 2. Patients aged 30-70 years old, willing to accept treatment and able to cooperate; 3. National Neurological Deficit Score (NIHSS) 16 < = NIHSS < = 30 points, moderate; 4. Western Aphasia Set (WAB) diagnosed as motor motor aphasia: aphasia quotient (AQ) < 93.8 points; The Chinese Aphasia Checklist (ABC) method was assessed as Broca-type aphasia; 5. The lesions are all on the left side; 6. The course of the disease is from June to October; 7. Right-handed, primary school education or above, native Chinese language; 8. Clear consciousness, no mental disorders and severe physical pain. 9. Stable condition, able to cooperate with the completion of fMRI scan; 10. Patients and their families voluntarily sign the informed consent form. Healthy control group: 1. No speech and language dysfunction; 2. Age 30-70 years old; 3. Right hand; Native Chinese speaker; 4. No brain trauma, mental disorders and other diseases.

Exclusion criteria

Exclusion criteria: Patient group: 1. Patients with severe dysarthria; 2. Those with severe physical disabilities; 3. Those with severe visual and auditory impairment affecting clinical evaluation and treatment; 4. Those with metal foreign bodies in the body, such as deep venous catheterization, claustrophobia and other contraindications to MRI scanning; 5. Patients with tumors, serious organs, endocrine system and other diseases; 6. Aphasia caused by other diseases; 7. Pregnant, lactating or planning to become pregnant in the past six months; 8. Those who have not completed the test due to other reasons. Healthy control group: 1. There are contraindications to MRI scanning such as metal foreign body and claustrophobia in the body; 2. Alcohol or drug addicts; 3. Pregnant, lactating or planning to get pregnant in the past six months; 4. Those who have not completed the entire test for other reasons.

Design outcomes

Primary

MeasureTime frame
Western aphasia battery,WAB score;ADL score;

Secondary

MeasureTime frame
NISS score;Blood oxygen levels are signal dependent;Changes in blood oxygen concentrations in the cerebral cortex;

Countries

China

Contacts

Public ContactJining Wang, Tiantian Liu

Shanghai Seventh People's Hospital

ccf978790568@163.com+86 177 6445 9068

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026