Acute ischemic stroke
Conditions
Interventions
Observation group:None
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=18 years old; 2. Preliminary judgment of acute ischemic stroke according to clinical symptoms and signs; 3. Imaging CT/MRI confirmed as acute ischemic stroke; 4. Receiving reperfusion therapy; 5. Signed written informed consent by the patient or family member.
Exclusion criteria
Exclusion criteria: 1.Intracranial hemorrhage confirmed by cranial CT or MRI; 2.Expected to be unable to complete the follow - up; 3.Patients deemed unsuitable for participation by the researchers; 4.Active internal hemorrhage; 5.Have had obvious hemorrhagic diseases currently or in the past 6 months; 6.Known history of intracranial hemorrhage or suspected intracranial hemorrhage; 7.Known bleeding diathesis; 8.Significant or recent severe or dangerous bleeding; 9.Central nervous system lesions or trauma history (such as intracranial tumors, arteriovenous malformations or aneurysms, intracranial or intraspinal surgery); 10.Aneurysmal subarachnoid hemorrhage or suspected subarachnoid hemorrhage; 11.Tumors with a bleeding tendency; 12.Bacterial endocarditis or pericarditis; 13.Have undergone cardiopulmonary resuscitation for a long time (> 2 minutes), childbirth or non - pressure vascular puncture (such as subclavian or jugular vein puncture) within the last 2 weeks; 14.Acute pancreatitis, active peptic ulcer, aneurysm or arteriovenous malformation. 15.Taking oral anticoagulant therapy with an INR > 1.3; 16.Severe liver diseases, including liver failure, cirrhosis, portal hypertension (esophageal varices) and active hepatitis; 17.Have had severe trauma or major surgery in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale Score;Incidence of symptomatic intracranial hemorrhage (SICH) within 48 hours after completion of tirofiban treatment and 90-day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| National Institute of Health Stroke Scale Score;EuroQol Five Dimensions Questionnaire Score;Incidence of asymptomatic intracranial hemorrhage (aSICH) within 48 hours;Incidence of non-intracranial bleeding complications (including gastrointestinal bleeding, urethral bleeding, oral or nasal mucosal bleeding, and subcutaneous hematoma);Incidence of non-hemorrhagic serious adverse events; | — |
Countries
China
Contacts
Public ContactHu Bo
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed