Helicobacter pylori infection
Conditions
Interventions
A group:Vonoprazan 20mg bid+Minocycline 100mg bid,14 days
B group:Vonoprazan 20mg bid+ Amoxicillin 1000mg tid, 14 days
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Participants voluntarily joined this study, signed informed consent forms, and demonstrated good compliance; 2. Age: 18 ~ 70 years old, both genders eligible; 3. Patients diagnosed with Helicobacter pylori infection: 13C/14C urea breath test; 4. Patients with initial treatment and retreatment of Helicobacter pylori can be included.
Exclusion criteria
Exclusion criteria: 1.Use of medications that may affect study outcomes within the past 4 weeks (proton pump inhibitors [PPIs], potassium-competitive acid blockers [P-CABs], H2 receptor antagonists [H2RAs], bismuth preparations, antibiotics);2.Patients with a previous Helicobacter pylori eradication regimen of Vonoprazan dual therapy or regimens containing Minocycline.3.Patients with malignant gastrointestinal tumors;4.History of gastric or esophageal surgery;5.Presence of severe comorbidities;6.Known allergic to drugs related to this study;7.Women in pre-conception period, pregnancy, or lactation;8.Patients unable to describe adverse events due to advanced age, psychiatric disorders, or other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of compliance;Factors influencing eradication rate;Alterations in the intestinal microbiota;Changes of gastrointestinal symptoms before and after treatment; | — |
Countries
China
Contacts
Public ContactDekui Zhang
Lanzhou University Second Hospital
Outcome results
None listed