advanced non-small-cell lung cancer
Conditions
Interventions
Experimental group:The observation group received immune checkpoint inhibitors between 6:00 and 7:00 in the morning (before 7:00 am)
control group:The control group received immune checkpoint inhibitors before 10:00-13:00 in the morning (until 13:00)
Sponsors
Henan Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: To be included in this study, all of the following selection criteria must be met: 1. Diagnosed with non-small cell lung cancer, in accordance with the Clinical Diagnosis and Treatment Guidelines for Lung Cancer of the Oncology Branch of the Chinese Medical Association (2021 edition), all confirmed by histological evidence, and clinically classified as tumor node metastasis (TNM) stage III-IV; 2. Age >= 18 years old; 3. Expected survival period >= 6 months; 4. The treatment plan adopts immune checkpoint inhibitors combined with chemotherapy for patients; 5. Good compliance, able to comply with clinical trial requirements and medication regulations; 6. The subject or guardian has signed an informed consent form.
Exclusion criteria
Exclusion criteria: Any of the following will not be included in this study: 1.Merge tumors other than lung cancer; 2. Individuals allergic to any ingredient in the medication; 3. Merge cognitive impairment, mental disorders, or unwillingness to cooperate; 4. Patients who take protective medical measures; 5. Individuals with severe liver and kidney dysfunction; 6. The researchers believe that patients who did not participate in this study are not eligible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS,Progression free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| ORR,Objective response rate;DCR,Disease control rate;OS,overall survival;Survival rate (1-year, 2-year, 3-year survival rate);The occurrence of immune related adverse events; | — |
Countries
China
Contacts
Public ContactQiming Wang; Gao Yana
Henan Cancer Hospital
Outcome results
None listed