Helicobacter pylori infection
Conditions
Interventions
Bismuth quadruple regimen + placebo group:Esomeprazole 20mgBid + amoxicillin 1.0g Bid+ clarithromycin 500mg Bid+ bismuth potassium citrate 220mgBid The course of treatment was 2 weeks. For patients al
Placebo was given orally in maltodextrin-containing capsules once a day for 4 weeks
Bismuth quadruple regimen + inactive bacteria intervention group:Bismuth quadruplex program + inactivated bacteria intervention group: Esomeprazole 20mgBid + amoxicillin 1.0g Bid+ clarithromycin 500mg
Bismuth quadruple regimen +active bacteria intervention group:Esomeprazole 20mgBid + amoxicillin 1.0g Bid+ clarithromycin 500mg Bid+ bismuth potassium citrate 220mgBid for 2 weeks. For patients allerg
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >18 years old. 2.Confirmed Helicobacter pylori infection (C13/14 breath test, rapid urease test, pathological examination). 3.Subject is able and willing to provide written informed consent and comply with the requirements of this study protocol.
Exclusion criteria
Exclusion criteria: 1. Patients who have used antibiotics or probiotics within 4 weeks. 2.Pregnant and lactating women. 3.Use of PPI, H2R, bismuth preparations within 4 weeks 4.Failure of first-line treatment of Helicobacter pylori infection within 3 months. 5.Previous allergy to probiotics. 6.History of gastrointestinal surgery. 7.Patients with a history of acute gastroenteritis within 4 weeks. 8.Patients with serious heart, liver, kidney and other organs and systemic diseases. 9.There are other circumstances in which the investigational drug is not considered appropriate for use by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastrointestinal symptom score;Quality of life score;Intestinal microecology; | — |
Countries
China
Contacts
Public ContactWensong Ge
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed