postoperative gastrointestinal dysfunction
Conditions
Interventions
D0:Control Group (D0): Patients will receive an infusion of normal saline throughout the surgery.
D1:Patients will receive an initial bolus dose of 0.5 µg/kg of dexmedetomidine over 10 minutes, followed by a continuous infusion of 0.2 µg/kg/h for the remainder of the surgery.
D2:Patients will receive an initial bolus dose of 0.5 µg/kg of dexmedetomidine over 10 minutes, followed by a continuous infusion of 0.4 µg/kg/h for the remainder of the surgery.
D3:Patients will receive an initial bolus dose of 0.5 µg/kg of dexmedetomidine over 10 minutes, followed by a continuous infusion of 0.6 µg/kg/h for the remainder of the surgery.
Sponsors
Zhongda Hospital, School of Medicine, Southeast University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1 American Society of Anesthesiologists (ASA) Physical Status Classification I-III. 2 Patients scheduled for gynecological laparoscopic surgery. 3 Patients or their legally authorized representatives agree to sign the informed consent form. 4 Patients aged between 18 and 75 years.
Exclusion criteria
Exclusion criteria: Exclusion Criteria 1 Known gastrointestinal motility disorders. 2 History of abdominal surgery. 3 Second-degree or higher heart block. 4 Preoperative baseline heart rate below 50 beats per minute (bpm). 5 Severe hepatic or renal dysfunction. 6 Difficult airway or history of delayed extubation. 7 Opioid abuse. 8 Allergy to dexmedetomidine or other anesthetics. 9 Expected postoperative transfer to the Intensive Care Unit (ICU). 10 Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to First Flatus; | — |
Secondary
| Measure | Time frame |
|---|---|
| First defecation time;I-FEED Score;Postoperative recovery quality;Pain score;Sleep score;Nausea and vomiting score;Perioperative vital signs;First eating time; | — |
Countries
China
Contacts
Public ContactMi Tian
Department of Anesthesiology, surgery and pain management, Zhongda Hospital, School of Medicine, Southeast University
Outcome results
None listed