Oral cancer
Conditions
Interventions
Sponsors
Peking University School and Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients with locally advanced oral squamous cell carcinoma diagnosed pathologically by biopsy and whose neoadjuvant treatment regimen is immune-combination therapy; 2.No previous tumor-related treatment including radiotherapy, chemotherapy, targeted therapy and immunotherapy; 3.Fresh specimens sufficient for cell culture can be obtained with conventional treatment; 4.No other malignancy previously diagnosed, or a malignancy diagnosed with a favorable prognosis, such as basal cell carcinoma of the skin; 5.ECOG fitness status is less than or equal to 2; 6.At least 1 measurable lesion (according to RECIST1.1).
Exclusion criteria
Exclusion criteria: 1. Major surgery not related to oral cancer within 4 weeks, or the patient has not fully recovered from such a surgical procedure; 2.Pregnant and lactating women; 3.Serious comorbidities that interfere with treatment plans; 4.Severe liver and kidney dysfunction and inability to tolerate immune-combination therapy; 5.Immunosuppression, active autoimmune disease or other conditions that may interfere with the study; 6.Cognitive impairment, mental illness, poor compliance; 7.Allergy to known components of chemotherapy, target therapy or immune therapy; 8.Other circumstances in which the researchers consider not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical objective response rate;PTC susceptibility result;Pathological Response Rate; | — |
Countries
China
Contacts
Public ContactShan Xiaofeng
Peking University School and Hospital of Stomatology
Outcome results
None listed