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Clinical study of the effect of TNF-alpha inhibitors on patients undergoing surgery for Crohn's disease

Clinical study of the effect of TNF-alpha inhibitors on patients undergoing surgery for Crohn's disease

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500099062
Enrollment
Unknown
Registered
2025-03-18
Start date
2023-02-01
Completion date
Unknown
Last updated
2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's disease

Interventions

TNFi-exposed and TNFi-naive:None

Sponsors

Sun Xiaomin Tongji University Tenth People's Hospital: Shanghai Tenth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients with a clear diagnosis of Crohn's disease based on clinical, imaging, endoscopic and post-operative pathology; 2. Patients undergoing bowel resection for the first time at our Inflammatory Bowel Disease Surgery Centre.

Exclusion criteria

Exclusion criteria: 1. Surgery for purely perineal surgery and abscess drainage, etc; 2. Unplanned reoperation for postoperative complications (e.g. surgery for postoperative bleeding, anastomotic leak, abdominal abscess and stoma complications; 3.Incomplete clinical information or loss of follow-up.

Design outcomes

Primary

MeasureTime frame
Effect of preoperative TNF-a inhibitor exposure on postoperative complications in patients;Effect of postoperative TNF-a inhibitor exposure on postoperative endoscopic recurrence in patient;

Secondary

MeasureTime frame
The effect of preoperative TNF-alpha inhibitor exposure on patients' surgical approach;The effect of preoperative TNF-alpha inhibitor exposure on patients' postoperative length of stay;Effect of postoperative TNF-a inhibitor exposure on postoperative complications in patients;

Countries

China

Contacts

Public ContactSun Xiaomin

Tongji University Tenth People's Hospital: Shanghai Tenth People's Hospital

sxmglcly@163.com+86 189 1828 9238

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026