Postpartum Depression
Conditions
Interventions
C group:The fetus was subjected to equal amounts of normal saline and tDCS sham stimulation after umbilical cord clamping. Patients receive only a 30-second current rise phase at the beginning and a 3
D group:Fetals were stimulated with 2 mA tDCS for 30 minutes after umbilical cord clamping. Electrical stimulation is delivered through 2 electrodes placed in a saline-soaked sponge, the electrodes ar
K group:After the fetus has clamped the umbilical cord, a one-time dose of esketamine 0.2 mg/kg will be given intravenously.
DK group:After the umbilical cord was clamped, the fetus was given a one-time intravenous dose of 0.2 mg/kg esketamine and simultaneously received 2 mA tDCS stimulation for 30 minutes. Electrical stim
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Singleton full-term pregnant women aged 18 to 35 years; 2.BMI 17-36 kg/m^2; 3. ASA Grading I-II; 4. Pregnant women without contraindications to neuraxial surgery. 5. In line with ethics, the patient voluntarily underwent the test and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Presence of contraindications or allergies to esketamine or other anesthetic agents; 2.Known or suspected abuse or long-term use of narcotic sedatives or analgesics; 3.Severe hypertension or severe cardiovascular disease; 4.History of any cerebrovascular accident within the past 3 months; 5.Pulmonary hypertension, or elevated intracranial or intraocular pressure; 6.Individuals with implanted cardiac pacemakers or other metal objects in their bodies; 7.Refusal to sign the informed consent form. 8.Severe psychiatric history, central nervous system injury, or cognitive dysfunction; 9.Severe hepatic or renal insufficiency; 10.History of use of antidepressants or other psychiatric medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Edinburgh Postnatal Depression Scale score on postoperative day 7; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative 24-hour pain score;Postoperative 72-hour pain score;Postoperative 24-hour Sleep Quality Score;Postoperative 72-hour Sleep Quality Score;Postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactMeiyan Zhou
Xuzhou Central Hospital
Outcome results
None listed