type A aortic dissection,TAAD
Conditions
Interventions
Experimental group:CPB/MHCA+HA380
Control group:CPB/MHCA
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The patient is 18-75 years old 2. The patient is TAAD, and the onset time is within 7 days 3. Signed informed consent
Exclusion criteria
Exclusion criteria: 1. Preoperative CTA suggests unilateral or bilateral renal artery pseudolumen blood supply 2. A previous history of renal insufficiency 3. Difficult to stop bleeding during surgery due to various reasons of taking anticoagulant and antiplatelet drugs before surgery, and the cardiopulmonary bypass time exceeds 6 hours 4. Severe organ perfusion is present before surgery, such as lower extremity ischemia or preoperative coma 5. BMI > 40 Kg/m^2 or pregnancy 6. Currently participating in other clinical trials 7. Cannot obtain the written consent of the patient or client.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AKI within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum CIRP expression level within 24 hours after surgery;Changes of serum IL-6 expression level within 24 hours after operation;Changes of serum TNF-a expression level within 24 hours after operation;Postoperative survival;Mechanical ventilation time;Postoperative hospital stay;postoperative infection;Postoperative SOFA score; | — |
Countries
China
Contacts
Public ContactZijian He
Guangdong Provincial People's Hospital
Outcome results
None listed