Postpartum depression
Conditions
Interventions
Control group:After delivery, 0.5ug/kg dexmedetomidine was injected intravenously for 10min, followed by PCIA pump: dexmedetomidine 100ug+ sufentanil 50ug+ normal saline, total 100ml, continuous flow
Experimental group:After delivery, 0.5ug/kg of dexmedetomidine and 0.3mg/kg of esketamine were injected intravenally for 10min, followed by PCIA pump: 100ug of dexmedetomidine + 50mg of esketamine + n
Sponsors
Wenzhou People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Women with cesarean section under neuraxial anesthesia; 2. > = 18 years old; 3. ASA Level II; 4. > gestation = 28 weeks; 5. Require postoperative intravenous self-controlled analgesia; 6. Preoperative Pittsburgh Sleep Quality Index (PSQI) >=7 points; 7. The mother can communicate well with the follow-up patients, understand the trial process and voluntarily participate in the study and sign the relevant informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of mental illness or depression in the past; 2. Severe cardiovascular and cerebrovascular diseases and liver and kidney insufficiency; 3. Have a history of psychotropic drugs and alcohol abuse; 4. Severe eclampsia; 5. Allergy to the drugs in this trial; 6. Placenta previa, placental abruption and other diseases with estimated blood loss greater than 800 ml before surgery; 7. Preoperative sinus bradycardia (maternal heart rate less than 50 beats/min), or abnormal heart conduction or heart rhythm diseases such as sick sinus syndrome; 8. Preoperative hypotension (standard systolic blood pressure less than 90mmHg and/or diastolic blood pressure less than 60mmHg); 9. Unable to understand the language of the follow-up and communicate well.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EPSD scores ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of self-harm ideation;LSEQ score;VAS score;Remedial analgesic situation;Surgical and anesthesia-related indicators;Postoperative conditions and adverse reactions; | — |
Countries
China
Contacts
Public ContactJing Chen
Wenzhou People's Hospital
Outcome results
None listed