Ischemic cerebrovascular disease
Conditions
Interventions
Sham group:Treatment was given 3 days before surgery, twice a day, 9-10 a.m., 4-5 p.m. Cuff pressure 60mmHg, pressurization 5min, open 5min, 5 cycles.
RIPreC group:Treatments were given 3 days before surgery, twice a day, 9-10 a.m., 4-5 p.m. Cuff pressure 200mmHg, pressurized 5min, open 5min, 5 cycles.
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 45~80 years old; 2. ASA Class I.-III; 3. Elective interbody fusion; 4. Preoperative ischemic cerebrovascular disease, modified Rankin scale (MRS) score 0~3; 5. Able to understand and comply with the requirements of the clinical trial protocol, and voluntarily sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1. Patients who are intolerant to the pre-adaptation of distant ischemia; 2. Patients with unsatisfactorily controlled hypertensive diseases, i.e., resting systolic blood pressure >=180mmHg, and/or diastolic blood pressure >=110 mmHg; Patients with hypotension, i.e., resting systolic blood pressure < 90 mmHg, and/or diastolic blood pressure < 60 mmHg; 3. Other conditions judged by the investigator that the patient is not suitable to participate in the clinical study; 4. Emergency surgery; 5. Combined with severe organ insufficiency/failure; 6. Cognitive dysfunction before surgery; 7. Patients with severe language impairment, vision and hearing impairment who cannot complete the scale examination;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of short-term PND;Neurological complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event;Complications of other organ systems;Length of stay;Total cost of hospitalization;Inflammatory factors and markers related to neuroinflammation and nerve injury;RNA sequencing; | — |
Countries
China
Contacts
Public ContactWang Tianlong
Xuanwu Hospital Capital Medical University
Outcome results
None listed