Cancer pain
Conditions
Interventions
Systematic implantation with intrathecal drug infusion + splanchnic nerve block:Systematic implantation with intrathecal drug infusion + splanchnic nerve block.
Systematic implantation with intrathecal drug infusion:Systematic implantation with intrathecal drug infusion.
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with upper abdominal malignancies (liver cancer, stomach cancer, pancreatic cancer, cholangiocarcinoma) who use opioids for analgesia; 2. Poor control of cancer pain, resting NRS>=4 points or eruption pain >=3 times a day, or inability to tolerate opioid side effects; 3. Opioid tolerance: Reduced responsiveness to opioids, requiring oral morphine > 60mg/ day or equivalent doses of other opioids to achieve the desired analgesic effect.
Exclusion criteria
Exclusion criteria: 1. Contraindications of intraspinal puncture; 2. Systemic infection or local infection of the surgical site; 3. Abnormal clotting and severe bleeding tendency; 4. The condition is serious and cannot tolerate cooperative surgery; 5. Allergic to the implanted catheter, pump and the drugs used in the pump; 6. Patients with cerebrospinal fluid circulation disorder due to intraspinal metastasis of tumor; 7. Severe mental illness; 8. Poor cognition or confusion; 9. Pregnant and lactating patients; 10. Unstable angina pectoris or cardiac obstruction in the past 6 months; Previous severe angina; Congestive heart failure; 11. The investigator determines that the subjects, including but not limited to major organ dysfunction and/or serious systemic diseases, are not suitable for participating in this clinical study; 12. Subarachnoid space injection of a single low dose of morphine hydrochloride test ineffective or serious adverse reactions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Average number of pain outbreaks per day;Morphine dosage;Insomnia severity index;Survival rate;Incidence of opioid-related adverse reactions;Effect evaluation at 7 days after treatment;Incidence of postoperative complications; | — |
Countries
China
Contacts
Public ContactLiao Lijun
Shanghai East Hospital
Outcome results
None listed