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A Comparative Study on the Efficacy of Subretinal Injection of Anti-VEGF Agents versus Intravitreal Injection of Anti-VEGF Agents in the Treatment of Refractory Diabetic Macular Edema

A Comparative Study on the Efficacy of Subretinal Injection of Anti-VEGF Agents versus Intravitreal Injection of Anti-VEGF Agents in the Treatment of Refractory Diabetic Macular Edema

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500098989
Enrollment
Unknown
Registered
2025-03-17
Start date
2025-04-01
Completion date
Unknown
Last updated
2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic retinopathy, vitreous hemorrhage with traction retinal detachment

Interventions

Intravitreal injection group(non-Exposure group):Intravitreal injection of anti-VEGF agents
Subretinal injection group(Exposure group):Subretinal injection of anti-VEGF agents

Sponsors

Affiliated Eye Hospital of Nanchang University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with diabetic retinopathy complicated by vitreous hemorrhage and tractional retinal detachment who underwent vitrectomy and silicone oil injection, and still had diabetic macular edema (DME) after three consecutive and regular anti-VEGF treatments, with a central retinal thickness (CRT) of the macula >300 µm.

Exclusion criteria

Exclusion criteria: Patients with significant opacification of the ocular media, making it impossible to obtain preoperative optical coherence tomography (OCT) images, a history of pars plana vitrectomy (PPV) surgery, significant retinal pigment epithelium (RPE) atrophy, active or high-risk proliferative diabetic retinopathy, tractional retinal detachment, neovascular glaucoma, and those with monocular vision.

Design outcomes

Primary

MeasureTime frame
Central macular thickness;

Countries

China

Contacts

Public ContactYou Zhipeng

Affiliated Eye Hospital of Nanchang University

yzp74@sina.com+86 791 86277161

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026