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The influence of preoperative buccal acupuncture intervention on postoperative pain and endocannabinoid receptors in total knee arthroplasty

The influence of preoperative buccal acupuncture intervention on postoperative pain and endocannabinoid receptors in total knee arthroplasty

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500098982
Enrollment
Unknown
Registered
2025-03-17
Start date
2025-04-01
Completion date
Unknown
Last updated
2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

Test group:Positioning treatment was carried out at the knee acupoint and popliteal fossa acupoint, and the needle was left for 30 minutes
Control group:Non-specific acupuncture points are used to penetrate the skin through pseudo-acupuncture, that is, plastic catheters can be retracted with false needles to open 0.5-5cm next to traditio

Sponsors

Ningxia Hui Autonomous Region People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Age 40-70 years old, gender is not limited; 2. American College of Anesthesiologists (ASA) classification I.~III.; 3. Diagnosed with osteoarthritis, it is planned to undergo primary selective unilateral total knee arthroplasty (TKA) under spinal anaesthesia; 4. There are no contraindications to buccal needle, femoral nerve and spinal anaesthesia; 5. No local anaesthetic allergy; 6. Able to cooperate and understand; 7. Obtain informed consent.

Exclusion criteria

Exclusion criteria: 1. Body mass index (BMI) 40; 2. Peripheral neuropathy; 3. severe renal impairment (requiring renal replacement therapy); 4. severe hepatic impairment (Child-Pugh grade C); 5. History of severe cardiovascular disease (NYHA > grade 2); 6. Other circumstances that the attending physician or investigator considers unsuitable to participate in this study;

Design outcomes

Primary

MeasureTime frame
NRS pain score at rest and during activity of total knee after TKA ;NRS pain score at rest and during activity at the back of the knee after TKA;

Secondary

MeasureTime frame
Detection of endocannabinoid receptors (CB1R, CB2R, and GPR55) in the synovial membrane of the knee;NRS pain scores of patients before and after buccal acupuncture intervention;Knee range of motion of patients before and after buccal acupuncture intervention;

Countries

China

Contacts

Public ContactShen Li

Ningxia Hui Autonomous Region People's Hospital

957566961@qq.com+86 182 4609 0494

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026