Knee osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 40-70 years old, gender is not limited; 2. American College of Anesthesiologists (ASA) classification I.~III.; 3. Diagnosed with osteoarthritis, it is planned to undergo primary selective unilateral total knee arthroplasty (TKA) under spinal anaesthesia; 4. There are no contraindications to buccal needle, femoral nerve and spinal anaesthesia; 5. No local anaesthetic allergy; 6. Able to cooperate and understand; 7. Obtain informed consent.
Exclusion criteria
Exclusion criteria: 1. Body mass index (BMI) 40; 2. Peripheral neuropathy; 3. severe renal impairment (requiring renal replacement therapy); 4. severe hepatic impairment (Child-Pugh grade C); 5. History of severe cardiovascular disease (NYHA > grade 2); 6. Other circumstances that the attending physician or investigator considers unsuitable to participate in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS pain score at rest and during activity of total knee after TKA ;NRS pain score at rest and during activity at the back of the knee after TKA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Detection of endocannabinoid receptors (CB1R, CB2R, and GPR55) in the synovial membrane of the knee;NRS pain scores of patients before and after buccal acupuncture intervention;Knee range of motion of patients before and after buccal acupuncture intervention; | — |
Countries
China
Contacts
Ningxia Hui Autonomous Region People's Hospital