Chronic kidney disease
Conditions
Interventions
Gold Standard:According to the clinical practice guidelines of the "Kidney Disease Outcomes Quality Initiative (KDOQI)", the diagnostic criteria and staging of Chronic Kidney Disease (CKD) are establi
Index test:MRI scanning sequences: T2-weighted imaging (T2WI), T1 Dixon sequence, T2* sequence, pseudo-continuous arterial spin labeling (pCASL), quantitative susceptibility mapping (QSM)
Laboratory indicators: serum creatinine (sCr), cystatin C (cyc-s), estimated glomerular filtration rate based on serum creatinine (sCr) or cystatin C (cyc-s) [eGFR-SCr or eGFR-Cys], neutrophil gelatin
Sponsors
Shanghai Municipal Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Diagnostic criteria and staging were developed according to the clinical practice guidelines of the Kidney Disease Prognostic Quality Initiative. Patients with 15 mL/min/1.73 m² <= sCr-eGFR < 45 mL/min/1.73 m² CKD were included. sCr-eGFR was calculated by the following formula: eGFR = 194 × serum creatinine?¹.°?4 × age?°.²87 (× 0.739 if female). At the time of enrollment, a range of candidate dependent variables was established by reading the literature, clinical experience, and data obtained from our previous studies, including age, sex, SBP/DBP, sCr (or cyc-s)-eGFR, hemoglobin, electrolyte potassium, presence or absence of diabetes mellitus, CKD stage, imaging parameters (blood flow, oxygen consumption, magnetic susceptibility), etc. Indicators of biochemical variables are collected by testing blood and urine samples.
Exclusion criteria
Exclusion criteria: 1. Acute kidney injury, renal artery stenosis, renal dialysis treatment, large space-occupying lesions of both kidneys (long axis diameter >= 20 mm), nephrectomy on one side, malignant tumors, cardiac insufficiency, liver cirrhosis and ascites. 2. Patients who have taken anticoagulant and antithrombotic drugs (aspirin, Plavix, etc.) and diuretics within 3 days before the MRI scan, and patients who refuse medical intervention or treatment since the discovery of abnormal renal function. 3. Patients with contraindications to MRI (such as metal artifacts in the scanning area, claustrophobia, pregnancy, age 70 years) are also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T2* values;Renal Blood Flow;QSM value;Kidney volume;R2* value;sCr;cyc-s;sCr-eGFR;NGAL;BUN;Upr;Blood Glucose ;Uric Acid;ß2-MG;RBP;Hb;Electrolyte Potassium;cyc -s-eGFR; | — |
Countries
China
Contacts
Public ContactYang Shuohui
Shanghai Municipal Hospital of Traditional Chinese Medicine
Outcome results
None listed