Preoperative anxiety
Conditions
Interventions
Control Group:According to the sequential method, the initial dose of ramazolam is 0.2mg/kg, and the adjacent gradient is 0.01mg/kg.
Anxiety group:According to the sequential method, the initial dose of ramazolam is 0.2mg/kg, and the adjacent gradient is 0.01mg/kg.
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Ability to sign informed consent and willing to comply with protocol requirements; age 18-65; American Society of Anesthesiologists rated I-II; elective colonoscopy; body mass index 18 kg / m2-30kg / m^2.
Exclusion criteria
Exclusion criteria: Refused to participate in the trial; Diagnosed with severe heart, brain, lung, liver, kidney, or metabolic disease; Neuromuscular disorders and psychiatric disorders; Patients with anemia or thrombocytopenia; Patients who are not cooperative and unable to communicate; History of colectomy or any intraabdominal surgery; Taking anti-anxiety drugs; Allergic or contraindication to benzodiazepines, opioids, propofol, flumazenil, naloxone and other drugs and their drug components; A history of alcohol abuse, opioid allergy, or abuse of such drugs; Patients with uncontrolled severe hypertension; Pregnant or lactating women; Other conditions deemed unsuitable for enrollment by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The median effective effect-concentration ;Complication; | — |
Secondary
| Measure | Time frame |
|---|---|
| The 95% effective effect-concentration ;95% confidence interval ;Mean arterial pressure ;Heart rate ;The Spielberg State-Trait Anxiety Scale score; | — |
Countries
China
Contacts
Public ContactMeng yan
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed