Anesthesia recovery quality and postoperative cognitive dysfunction
Conditions
Interventions
Propofol group:Sufentanil 0.3-0.5ug/kB, etomidate 0.3-0.5mg/kg, cisatracurium besilate 0.1-0.2mg/kg, and lidocaine 50mg for anesthesia induction. During anesthesia maintenance, sevoflurane and remifen
Sevoflurane group:Sufentanil 0.3-0.5ug/kg, etomidate 0.3-0.5mg/kg, cisatracurium besylate 0.1-0.2mg/kg and lidocaine 50mg for anesthesia induction, and sevoflurane and remifentanil will be used throug
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
66 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age greater than 65 years old; 2. American Society of Anesthesiologists (ASA) Physical Status I-III; 3. Primary school education or above; 4. Negative bell painting test; 5. MMSE score> 23 points; 6. Operation time>3h; 7. Sign the informed consent form and voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: 1. Age> 85 years; 2. Neurosurgery and cardiac surgery; 3. Patients with a history of neurological diseases, stroke, other significant central nervous system diseases or severe psychiatric diseases, multiple trauma and head trauma, endocrine or metabolic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Time to extubation;Quality of Recovery-40 (QoR-40) questionnaire;Mini-Mental State Examination score, MMSE scores;Aldrete recovery score;Length of PACU stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay sedation score;Visual Analogue Scale;Cough up;Agitation;Shiver; | — |
Countries
China
Contacts
Public ContactXue Li; Di Zhang
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed