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Optimization of human NK cell in vitro expansion culture system and related functional evaluation

Optimization of human NK cell in vitro expansion culture system and related functional evaluation

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500098976
Enrollment
Unknown
Registered
2025-03-17
Start date
2025-04-01
Completion date
Unknown
Last updated
2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver disease

Interventions

Pregnant women:NA
Tumor patients:NA

Sponsors

The Third Affiliated Hospital, Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Pregnant women: Inclusion criteria: 40 expectant mothers, aged 22 to 35, from Lingnan Hospital, the Third Affiliated Hospital of Sun Yat-sen University. Be able to communicate well with investigators and understand and comply with the requirements of this study. 2. Healthy volunteers Inclusion criteria: 50 healthy volunteers from Lingnan Hospital, the Third Affiliated Hospital of Sun Yat-sen University. 18-85 Years old, 10ml of peripheral blood was collected; he was able to endure venipuncture and had no history of blood or needle sickness; had good communication with the investigator, and understood and complied with the requirements of this study. 3. Tumor patients Inclusion criteria: 50 cancer patients (liver cancer, lung cancer, colon cancer, urinary system tumors, breast cancer, etc.) from Lingnan Hospital, the Third Affiliated Hospital of Sun Yat-sen University. 18-85 Years old; can tolerate venipuncture and have no history of blood or needle sickness; communicate well with the investigator, and understand and abide by the requirements of this study.

Exclusion criteria

Exclusion criteria: 1. Pregnant women: Exclusion criteria are: exclusion of infectious diseases such as hepatitis B; exclusion of serious complications that are inconvenient to collect cord blood; exclusion of those who need to preserve cord blood donors. 2. Healthy volunteers: Exclusion criteria are: exclude anemia and it is inconvenient for volunteers to collect blood. 3. Tumor patients: Exclusion criteria are: Exclusion of those with serious complications and inconvenient blood collection.

Design outcomes

Primary

MeasureTime frame
NK cell percentage and molecules related to NK cell function;Mixed and co-cultured with tumor cell lines (target cells) to detect apoptosis of tumor cell lines;

Countries

China

Contacts

Public ContactXu Yan

The Third Affiliated Hospital, Sun Yat-sen University

xuyan55@mail.sysu.edu.cn+86 180 2800 5832

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026