Acute lung injury after surgery
Conditions
Interventions
Group A (sivelestat sodium) :Group A (sivelestat sodium group) : the patients were given sivelestat sodium 4.8 mg/kg+50 ml normal saline, which was continuously pumped for 24 h away from light, equiva
It has been applied for 5 consecutive days.
Group B (saline control):Group B (normal saline control group) : 50 ml normal saline was given, continuously pumped intravenously for 24 h, and continuously applied for 5 days.
Sponsors
Shaoxing People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) ALI/ARDS patients aged >=18 years; (2) Meet the Berlin diagnostic criteria (see annex); (3) Patients who can be administered within 72 hours of the onset of ALI/ARDS; (4) Can understand and comply with the requirements of the agreement, and voluntarily sign the informed consent;
Exclusion criteria
Exclusion criteria: (1) Patients participating in other clinical studies; (2) Patients with serious lack of diagnosis and treatment data; (3) Pregnant women, breastfeeding women or women who may be pregnant; (4) Patients who, as judged by the investigator, are not suitable for the study group (such as patients suffering from mental illness); (5) Patients diagnosed with primary neutropenia (absolute neutrophil count <2?109/L);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index (PaO2/FiO2) and 28 days of mechanical ventilation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory markers at day 0, 1, 3, 5: WBC, CRP, PCT, IL-6;Overall outcome of ARDS: length of stay in ICU, ICU mortality, in-hospital mortality, 28-day mortality;Safety indicators: Blood routine, liver and kidney function, coagulation function at day 0, 1, 3 and 5;Adverse event;Scores: SOFA score at day 0, 1, 3 and 5, APACHE II, Murray lung injury score, chest radiograph /CT score; | — |
Countries
China
Contacts
Public ContactXuedong Sun
Shaoxing People's Hospital
Outcome results
None listed