Depressive disorder
Conditions
Interventions
Attention Bias Intervention Training True Intervention Group(Part 2):The E-Prime experimental software was used to present the experimental task. The attention bias task was programmed using a point d
the process of the task: (1) the attention point "E" and "F" were used in the task. (1) The focus point "+" appeared in the center of the screen, and the presentation time was 500 ms
(2) "+" disappeared, and a picture of an emotional face appeared on the left and right sides of the screen (neutral-negative matching), and the presentation time of the emotional face was 500 ms
emotional face Selected from the Chinese Faces and Emotions Picture System, there were 8 negative faces and 8 neutral faces, and half of the faces were male and half were female
(3) the emotional faces disappeared, and the target of the response appeared on the side of the screen, and the target of the response was the letter "E" or "F", and the target subjects were asked to
Sponsors
Hefei Fourth People's Hospital
Eligibility
Sex/Gender
All
Age
13 Years to 18 Years
Inclusion criteria
Inclusion criteria: Case group: 1. aged 13-18 years old, Han Chinese, with right-handedness as the dominant hand; 2. meeting the diagnostic criteria for major depressive disorder in the U.S. Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5); 3. without significant hearing and visual impairment; 4. without contraindications to magnetic resonance examination.According to the DSM-5, depressive disorder is considered to be accompanied by anxiety distress when the person with the disorder has at least two of the following symptoms: (1). feeling agitated or tense; (2). feeling unusually fidgety; (3). having difficulty concentrating because of worry; (4) fearing that something terrible may happen; (5). feeling that they may be losing self-control; based on the above criteria, we categorized adolescents with major depressive disorder into the group with anxiety distress group (MDD/ADS+) and the group without anxiety distress (MDD/ADS-). Healthy control group: healthy adolescents matched for age, sex, and years of education to patients with adolescent depressive disorders recruited in general secondary schools during the same period.
Exclusion criteria
Exclusion criteria: Case group: 1. history of epilepsy, coma, traumatic brain injury, and psychoactive substance use; 2. comorbid neurologic disorders or somatic disorders that may cause neurologic pathology; 3. comorbid severe somatic disorders; 4. contraindications to MRI scanning, such as artificial implants in the body, claustrophobia, etc.; 5. inability to cooperate with the completion of the attentional bias task and the MRI scan; Healthy control group: exclusion criteria were consistent with the case group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| anxiety level;Depression level; | — |
Secondary
| Measure | Time frame |
|---|---|
| the values of attentional bias ; | — |
Countries
China
Contacts
Public ContactZhong Hui
Hefei Fourth People's Hospital
Outcome results
None listed