Helicobacter pylori Infection
Conditions
Interventions
Helicobacter pylori infection group:None
Normal control group:None
Sponsors
Huadong hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1). Age between 18 and 60 years; (2). For the H. pylori-infected group, diagnosis must be confirmed by a carbon-13 urea breath test or rapid urease test during gastroscopy; for the healthy control group, there should be no significant gastrointestinal discomfort symptoms, and the urea breath test must be negative; (3). Relatively stable dietary habits with no major changes in diet structure, and similar lifestyle, dietary habits, and occupational activities; (4). Willingness to participate in the experiment and signing of the informed consent form; (5). Body Mass Index (BMI) between 18 and 24; (6). Absence of underlying digestive system diseases.
Exclusion criteria
Exclusion criteria: (1). Previous standardized treatment for Helicobacter pylori eradication; (2). Use of antibiotics, bismuth preparations, probiotics, etc., within the last 4 weeks, or use of potassium-competitive acid blockers, PPIs (proton pump inhibitors), or H2 receptor antagonists within the last 2 weeks; (3). Concurrent use of non-steroidal anti-inflammatory drugs (NSAIDs), systemic corticosteroids, anticoagulants, or excessive alcohol consumption during the treatment period; (4). Smokers; (5). Presence of systemic diseases; (6). Pregnancy or lactation; (7). Inability or unwillingness to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oral Microbial Communities;gut Microbial Communities;Metabolism; | — |
Countries
China
Contacts
Public ContactXiaowen Li
Huadong hospital, Fudan University
Outcome results
None listed