Diabetes
Conditions
Interventions
Intervention Group:4L PEG fractional lavage
Control group:4L PEG fractional lavage
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Participants must meet all of the following 4 conditions: 1. Aged between 18 and 75 years, regardless of gender; 2. Diagnosed with type 2 diabetes and currently receiving GLP-1 receptor agonist treatment for more than 8 weeks (no restrictions on the type of GLP-1 receptor agonist); 3. Plan to undergo colonoscopy (including screening, diagnostic, surveillance colonoscopy); 4. Voluntarily join this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Known or suspected allergy to bowel preparation drugs, such as PEG; 2. Suspected or confirmed bowel obstruction, bowel perforation, or foreign body in the bowel; 3. Toxic megacolon; 4. Uncontrolled hypertension (systolic blood pressure >170 mmHg, diastolic blood pressure >100 mmHg); 5. Shock or hemodynamic instability; 6. Severe electrolyte disturbances; 7. Coagulation disorders (prolonged prothrombin time (PT) greater than 3 seconds above the normal upper limit); 8. Congestive heart failure (New York Heart Association functional class III or IV); 9. Respiratory failure; 10. Decompensated cirrhosis; 11. Severe renal impairment (estimated glomerular filtration rate (eGFR) <30 ml/min); 12. Thoracoabdominal aortic aneurysm; 13. History of stroke, acute myocardial infarction, or unstable angina within the past 6 months; 14. History of colon surgery; 15. Pregnant or breastfeeding women; 16. Use of prokinetic drugs within the past week; 17. If the patient is using a long-acting GLP-1 receptor agonist, the drug discontinuation period exceeds 3 half-lives; 18. Severe constipation (as assessed by the Chronic Constipation Severity Score (CSS), exclusion if the score is greater than 15); 19. Participation in other drug/device studies or in the follow-up period of another drug/device study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bowel Preparation Adequacy Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Boston Bowel Preparation Scale Score;Cecal Intubation Rate;Cecal Intubation Time;Polyp Detection Rate;Adenoma Detection Rate;Tolerability of bowel preparation;The willingness of subjects to undergo similar bowel preparation in the future; | — |
Countries
Chian
Contacts
Public ContactKai Deng
1. Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China 2. Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Sichuan University, Chengdu 610041, Sichuan
Outcome results
None listed