Extremely Preterm Infants with Severe Intracranial Hemorrhage
Conditions
Interventions
case group (severe adverse neurological outcome group):None
control group:None
Sponsors
Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1.Infants with a gestational age of 24 to 27+6 weeks underwent cranial monitoring in the coronal and sagittal planes via the anterior fontanelle by a dedicated professional using an ultrasound device (probe frequency 7.5 MHz) within 3 to 10 days after birth. In cases where intracranial hemorrhage was detected, and subsequent follow-up within one month revealed progressive ventricular dilation or parenchymal hemorrhage (Grade III or IV intracranial hemorrhage) necessitating cerebrospinal fluid drainage, parental consent was obtained with the signing of an informed consent document;
Exclusion criteria
Exclusion criteria: 1.congenital malformation ?inherited metabolic diseases?Central Nervous System Infection ?bilirubin encephalopathy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in cerebrospinal fluid glycoprotein non-metastatic melanoma protein B levels between the case group and the control group;Difference in serum GPNMB levels between the case group and the control group; | — |
Countries
China
Contacts
Public ContactRuiwei Gao
Children's Hospital of Fudan University
Outcome results
None listed