Immunomyocarditis
Conditions
Interventions
Positive Group:Patients at our hospital who underwent immune checkpoint inhibitor (ICI) therapy between January 1, 2018, and November 1, 2024, and subsequently developed myocarditis associated with ch
Control Group:Patients at our hospital who received immune checkpoint inhibitor (ICI) therapy between January 1, 2018, and November 1, 2024, and did not develop myocarditis related to immune checkpoin
Sponsors
First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
19 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1. Screen patients who received immune checkpoint inhibitor (ICI) therapy at our hospital between January 1, 2018, and November 1, 2024; 2. Include only those patients who had no pre-existing cardiac organic lesions, no history of cardiovascular diseases, and showed no indications of heart disease in their laboratory tests, electrocardiograms, or imaging studies prior to ICI treatment.
Exclusion criteria
Exclusion criteria: 1. Inability to obtain complete clinical and imaging data; 2. Patients with pre-existing cardiac organic lesions or a history of heart-related conditions prior to ICI administration; 3. Patients who develop signs of myocardial injury after ICI treatment, requiring exclusion of differential diagnoses such as myocardial infarction, stress cardiomyopathy, primary dilated cardiomyopathy, and isolated acute pericarditis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gender;Age;Race;Drinking history;Smoking history;Tumor Type;Cancer Staging;Body Mass Index;History of diabetes;Comorbid Disease Category;ICI Drug Types;ICI Drug Dosage;ICI Drug with Radiotherapy Combination;ICI Drug with Chemotherapy Combination;blood routine examination;routine chemistry panel;liver function test;Renal function test;myocardial enzyme;Inflammatory index;coagulation indicator;Electrocardiograph; ultrasonic cardiogram;Accuracy;Area Under the Receiver Operating Characteristic Curve;AUC;Confusion Matrix; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac magnetic resonance; | — |
Countries
China
Contacts
Public ContactWei Wang
First Affiliated Hospital of Army Medical University
Outcome results
None listed