Type 2 diabetes
Conditions
Interventions
Type 2 diabetes without cognitive impairment group
:nothing
type 2 diabetes with cognitive impairment group
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
40 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Normal control group: (1) Fasting blood glucose 26 points; 2. T2DM without MCI group: (1) Consistent with the 2020 ADA (American Diabetes Association) diabetes diagnostic criteria: fasting plasma glucose (FPG) >= 7.0 mmol/L and HbA1c >= 6.5%, with 2-hour post-meal blood glucose >= 11.1 mmol/L; (2) Montreal Cognitive Assessment (MoCA) score > 26 points; 3. T2DM with MCI group: (1) Consistent with the 2020 ADA (American Diabetes Association) diabetes diagnostic criteria: fasting plasma glucose (FPG) >= 7.0 mmol/L and HbA1c >= 6.5%, with 2-hour post-meal blood glucose >= 11.1 mmol/L; (2) Montreal Cognitive Assessment (MoCA) score = 40 years T2DM group patients with a disease duration >= 3 years No significant language, visual, or auditory impairments Able to read and write independently Capable of cooperating with neuropsychological assessments Voluntarily participating in the study and signing informed consent Approved by the hospital’s ethics committee.
Exclusion criteria
Exclusion criteria: (1)Diagnosed with type 1 or other forms of diabetes; (2)Experience of grade 2 hypoglycemia (<3.0 mmol/L); (3)Women within 6 months postpartum; (4)Severe dysfunction of the heart, lungs, liver, or kidneys significantly impacting quality of life; (5)Severe comorbid conditions (e.g., cancer, infection, severe anemia) or acute diabetic complications; (6)Recent stroke, transient ischemic attack (TIA), encephalitis, or head trauma; (7)Epilepsy, Parkinson’s, depression, or other serious psychiatric or neurological disorders; (8)Frequent alcohol abuse or recent use of cognitive-impairing substances; (9)Severe communication, hearing, or vision impairments; (10)Unqualified blood samples or incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ROS and Relative Mitochondrial DNA Content of PBMC;Interleukin-10;Tumor Necrosis Factor Alpha;Cognitive function;Mental state;8-Hydroxy-2'-deoxyguanosine; | — |
Countries
China
Contacts
Public ContactShihong Chen
The Second Hospital of Shandong University
Outcome results
None listed