myocardial injury after non-cardiac surgery
Conditions
Interventions
Group K:Anesthesia induction: midazolam 0.03mg/kg, etomidate 0.2mg/kg, cisatracurium benzoate 0.15mg/kg, Sufentanil 0.3-0.6µg/kg, esketamine 0.5mg/kg
Anesthesia maintenance: propofol 4-12mg/kg/h, remifentanil 0.1-1.0ug/kg/min, esketamine 0.25mg/kg/h, benzoate cisatracurium intermittent intravenous infusion to maintain good muscle relaxation
Group C:Anesthesia induction: midazolam 0.03mg/kg, etomidate 0.2mg/kg, cisatracurium benzoate 0.15mg/kg, Sufentanil 0.3-0.6µg/kg
Anesthesia maintenance: propofol 4-12mg/kg/h, remifentanil 0.1-1.0ug/kg/min, intermittent intravenous infusion of cisatracurium bensulate to maintain good muscle relaxation
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age>=45 years old 2.ASA grade II-III 3.BMI of 18.5-28.0kg/m^2 4.Radical resection of esophageal cancer should be performed at an appropriate time 5.No communication barriers, clear consciousness; 6.Ethical, voluntary test, signed informed consent
Exclusion criteria
Exclusion criteria: 1.There is contraindication or allergy to esketamine and other narcotic drugs 2.History of mental illness, central nervous system injury 3.Identified/suspected abuse or long-term use of narcotic sedatives and analgesics 4.A history of serious cardiovascular disease (e.g., myocardial infarction, heart failure) 5.Serious infection: such as sepsis 6.Severe liver and kidney function damage 7.Preoperative troponin I>30ug/ml 8.Refusal to sign informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative myocardial injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative hemodynamic changes;Perioperative blood gas analysis;Perioperative inflammatory factor and anti-inflammatory factor levels;The incidence of perioperative arrhythmias (atrial fibrillation, supraventricular tachycardia, ventricular premature beat >=6 times /min);Incidence of postoperative adverse reactions to esketamine;pain;Duration of stay in the recovery room;Discharge time; | — |
Countries
China
Contacts
Public ContactZhou Hai
Xuzhou Central Hospital
Outcome results
None listed