Postoperative sleep disturbances
Conditions
Interventions
Dexmedetomidine-esketamine group:Dexmedetomidine hydrochloride injection, esketamine hydrochloride injection
Placebo group:0.9% sodium chloride injection
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Non-cardiac surgery under general anesthesia with an estimated duration of =60 minutes and an end time of no later than 18:00; 3. A patient-controlled intravenous analgesic pump is required postoperatively;
Exclusion criteria
Exclusion criteria: 1. Emergency surgery, transurethral surgery, organ transplants; 2. Pregnant or lactating women; 3. Patients who need hypnotics for sleep disturbance or antidepressants for depression prior to surgery; 4. History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis; 5. Inability to communicate due to coma, severe dementia, or speech disorders, hypoxic encephalopathy, craniocerebral injury, or postoperative neurosurgery; 6. Combined history of hyperthyroidism and pheochromocytoma; 7. Preoperative LVEF <30%, sick sinus node syndrome, severe sinus bradycardia (heart rate <50 beats/min), atrioventricular block of degree II or higher without pacemaker implantation, or systolic blood pressure below 90 mmHg despite the use of antihypertensive drugs prior to enrollment; 8. Patients with a diagnosis of sleep apnea (diagnosis of sleep apnea, or high-risk patients with moderate-to-severe sleep apnea as assessed by STOP-Bang); 9. Severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (on dialysis), or ASA classification =IV; 10. Hypersensitivity to dexmedetomidine and/or esketamine; 11. Other circumstances that the researcher felt were not appropriate for inclusion in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sleep disturbances within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index (PSQI) score on the 30th postoperative day;Richards-Campbell Sleepiness Questionaire (RCSQ) scores on the morning of postoperative days 1, 2, and 3;The Quality of Recovery-15 (QoR-15) score at 24 hours postoperatively.;NRS score at rest and during activity within the first 3 postoperative days;Hospital Anxiety and Depression Scale score on postoperative day 3; | — |
Countries
China
Contacts
Public ContactMo Li
Peking University First Hospital
Outcome results
None listed