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Study on the effective dose of tegileridine combined with propofol in hysteroscopic surgery

Study on the effective dose of tegileridine combined with propofol in hysteroscopic surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500098862
Enrollment
Unknown
Registered
2025-03-14
Start date
2025-03-16
Completion date
Unknown
Last updated
2025-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hysteroscopy surgery

Interventions

Experimental group:All patients were injected with intravenous tilgilidine fumarate for 9 minutes 10 minutes before operation, and propofol 2 mg/kg 1 minute before surgery. The initial dose of Tygilid

Sponsors

Lianyungang Maternal and Child Health Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective hysteroscopic surgery; 2. Age 18-60 years old; 3. ASA classification I.-II; 4.BMI18-25kg/m^2 ; 5. No respiratory disease and normal airway assessment before surgery.

Exclusion criteria

Exclusion criteria: 1. Refusal to sign informed consent; 2. Allergy to experimental drugs; 3. Abnormal vital signs or abnormal clinical laboratory test results; 4. Long-term use of opioids, analgesics, sedative drugs or a history of alcoholism; 5. Have a mental illness or are unable to communicate.

Design outcomes

Primary

MeasureTime frame
The 90% effective dose of tegileridine for inhibiting the cervical dilation response;

Secondary

MeasureTime frame
The general information of the patient, including age, height, weight, BMI, ASA classification and the name of the proposed surgical procedure, etc.;Total amount of propofol;The patient's heart rate at admission, successful induction, end of examination, and discharge;Adverse reactions include nausea, vomiting, asphyxia, dizziness, hypoxemia, bradycardia and hypotension.;Titili fumarate quantitative;Number of body motor reactions;Time to recovery from anesthesia (time from stopping propofol to opening the eyes as instructed);Check the time;Pain score upon exit from the PACU;Non-invasive blood pressure;Oxygen saturation;

Countries

China

Contacts

Public ContactYan Jiane

Lianyungang Maternal and Child Health Hospital

672694832@qq.com+86 180 3662 6197

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026