None
Conditions
Interventions
Lidocaine Group (L Group):A loading dose of lidocaine at 1.5 mg/kg will be administered via intravenous bolus during anesthesia induction. During the surgery, continuous intravenous infusion will be m
Remimazolam Group (R Group):A loading dose of remimazolam at 0.05 mg/kg will be administered via intravenous bolus during anesthesia induction. During the surgery, continuous intravenous infusion will
Sponsors
Ningbo Medical Center Lihuili Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Adult patients aged 18 to 65 years; 2.Scheduled for elective thyroid surgery with planned intraoperative nerve monitoring; 3.Classified as American Society of Anesthesiologists (ASA) grade I to II; 4.Body Mass Index (BMI) between 18.5 and 25 kg/m²; 5.Patients capable of cooperating with intraoperative nerve monitoring procedures; 6. Patients without a high risk of difficult airway.
Exclusion criteria
Exclusion criteria: 1. Patients with a known allergy to lidocaine or remimazolam; 2.Patients with severe cardiac, hepatic, or renal dysfunction; 3.Patients with neuromuscular disorders (e.g., myasthenia gravis); 4.Pregnant or lactating women; 5.Patients with a history of thyroid or neck surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the waveform morphology scores of recurrent laryngeal nerve monitoring ; the laryngeal reflex ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic Changes;depth of anesthesia; muscle relaxation level ;Awakening Time; Visual Analog Scale (VAS) pain scores ; adverse reactions; basic clinical data; | — |
Countries
China
Contacts
Public ContactZhou Longyuan
Ningbo Medical Center Lihuili Hospital
Outcome results
None listed